Macrolide-ResistantShigella sonnei

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Macrolide-Resistant Shigella sonnei

Shigella sonnei UCN59, isolated during an outbreak of S. sonnei in January 2007, was resistant to azithromycin (MIC 64 mg/L). The isolate contained a plasmid-borne mph(A) gene encoding a macrolide 2 -phosphotransferase that inactivates macrolides. Emergence of the mph(A) gene in S. sonnei may limit usefulness of azithromycin for treatment of shigellosis.

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ESBL-Producing and Macrolide-Resistant Shigella sonnei Infections among Men Who Have Sex with Men, England, 2015

In England in 2015, Shigella sonnei isolates from men who have sex with men produced extended-spectrum β-lactamases and exhibited macrolide resistance. Whole-genome sequencing showed a close relationship among the isolates, which harbored a plasmid that was previously identified in a shigellosis outbreak among this population but has acquired a mobile element.

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Ampicillin resistance of Shigella sonnei.

The ampicillin resistance of clinical isolates of Shigella sonnei is due to beta-lactamase production. Two kinds of resistance are found: low level, nontransmissible; and high level, tranmissible. The nontransmissible type of resistance results from a chromosomal mutation which increases the production of a beta-lactamase that hydrolyses cephalosporins relatively rapidly and gives cephalothin r...

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Salicin fermentation by Shigella sonnei.

Shigella species are generally considered to be unable to ferment salicin (Breed, Murray, and Smith, Bergey's Manual of Determinative Bacteriology, The Williams & Wilkins Co., Baltimore, 1957; Kauffmann, Enterobacteriaceae, E. Munksgaard, Copenhagen, 1950; Edwards and Ewing, Identification of Enterobacteriaceae, Burgess Publishing Co., Minneapolis, 1955). Recently, however, Ser6ny (Acta Microbi...

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Colicin typing of Shigella sonnei.

The colicin typing method for differentiating epidemic strains of Shigella sonnei was evaluated. Forty percent of the strains were untypable, but the method divides 60% of the strains into 15 established colicin types. The method has reasonably good reproducibility, but should not be interpreted with the same degree of confidence as some other characteristics such as serotypes. For this reason,...

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ژورنال

عنوان ژورنال: Emerging Infectious Diseases

سال: 2008

ISSN: 1080-6040,1080-6059

DOI: 10.3201/eid1408.080147